After defeating Eyghon, Spike suggests that he and Faith celebrate together with drinks. Faith, however, turns her attention to Angel, who had lost all sense in the wake of the battle. At the apartment, Spike, Faith and Alasdair Coames discuss possible solutions to their predicament; they choose to follow Alasdair's knowledge in order to retrieve the Essuary, a mystical item within which they could store the fragments of Giles' soul. The artifact was in the possession of Enders, a breed of soul-consuming demons. Before Spike and Faith go off in search of it, they choose to lock Angel in her basement.
Later that night, at a cemetery, Spike and Faith engaged the Enders in combat. Spike almost has his soul consumed, but manages to defeat the Ender responsible in the nick of time. After witnessing Spike's fear of having his soul stolen first hand, Faith gives Spike permission to sit out the fight; Spike, however, decides to risk it in order to help her defeat the Enders. They descend into a Victorian crypt, where they discuss their love lives. When Faith reveals that she and Robin Wood had broken up, Spike makes a misguided attempt to flirt with her. She declines, and states openly that she's "nobody's rebound girl." Spike admits to Faith that he is still in love with Buffy as they recover the Essuary from the crypt.
Later at the house, they celebrate their victory. Lavinia and Sophie make a pass at Spike, but ultimately reject him, rightly justifying that he looks like the type to "get attached" to women. Alasdair then calls Faith and the sisters to help him perform the ritual, and sends Spike to the basement to watch over Angel. Spike rants to Angel in a moment of emotional weakness about his own insecurities in regards to his relationship with Buffy.
Meanwhile, Faith makes a heartfelt appeal to Giles' soul to leave Angel's body. In the basement, Spike admits to Angel that he admires him for his ability to move on from Buffy. Much to Spike's surprise, Angel suddenly replies coherently that he hasn't moved on from Buffy. Embarrassed that he had admitted so much to Angel, Spike makes an attempt to brush off his words. Angel thanks Spike for helping him by texting him Harmony's phone number in order to get his spirits up.
The next morning, Angel and Faith discover Harmony in their shower, together with Spike. Faith jokes that Spike is using Harmony as a rebound, and then goes to get breakfast with Angel.
Spike quipped that killing a Big Bad didn't turn himself into a pile of ashes, referring to when he had defeated The First and closed the SunnydaleHellmouth in "Chosen".
Spike stated that Angelus and Angel were separate beings, something shown in "Orpheus".
Faith apparently knew that Buffy had died twice and was resurrected.
Spike and Faith's relationship is depicted as flirty and playful despite her rejection of his pass at her. This type of chemistry between them was heavily implied earlier in "Dirty Girls".
Faith also mentioned that Spike probably left Buffy with the reason that the relationship wasn't good for either of them, just like Angel in "The Prom". She was half right as before trying to be with her again, Spike distanced himself from Buffy because he wanted someone normal for her in "Freefall".
During her talk with him, Faith compared Spike to Angel. Upon her first official meeting with him, she had done the exact same, telling Buffy he was "like Angel" (Buffy responding with a "Sort of"). Spike once again denied it with fervor, also similar to the occurrence in "Dirty Girls".
Spike's solution to depression was again enforced to be drinking alcohol. He also, in a drunken state, once rambled aimlessly to Angel's mansion about his loss of Drusilla. Similarly, he also blamed him for his failure with her like he did in "Lovers Walk".
Spike used sex to cope with his depression and attempt at "moving on". He had slept with Anya in "Entropy" for the exact reason and person.
Harmony and Spike sleep together, the first time since "Destiny".
Angel and Spike have a slight bonding moment with each other, able to relate to each other in their painful love for Buffy. They earlier did the same in "The Girl in Question" when they believed she was dating The Immortal.
Faith: "I've got an idea. Why don't we just stake Angel, right here and now? Problem solved. No Angel, no Giles. Life easier for everyone. All right! I was just putting it out there. Saying what you were all thinking. I wasn't thinking it. I'm gonna find those Enders. I'm gonna kill'em. I'm gonna get this MacGuffin and use it to save Angel and Giles. Anyone who wants to help, speak up. Anyone who doesn't, screw you."
Spike: " (holds up chains) "Well, someone's been a naughty girl. Or did this belong to old Rupert? Wouldn't surprise me. Those tweedy sorts always keep bondage gear under their bed."
Faith: "I don't think we need the leg irons. And you're not funny."
Spike: "I am nothing like Angel!"
Faith: "Sure you are. Vampire with a soul, hung up over Buffy, fighting your own kind... you understand each other better than anyone on Earth. That's why you've got this whole backdoor bromance going on."
Faith: "You won't get over Buffy by getting laid. But you'll probably get laid when you get over Buffy."
Spike: "This is entirely your fault, you know. 'Look at me, I have a soul now! I brood. I flagellate myself. I have oh, so many feelings. I'm worthy of the Slayer.' And, of course, for you it works like a bloody charm. So like a right wanker, I put myself through unimaginable agony... By choice, unlike some people in my room. I win my soul back. So I won't be a monster anymore. Never asking myself if perhaps a monster was what she wanted."
Spike: "I'll tell you this, mate! I'd give anything to know how you got over her!"