Metcalf attended Westfield High School in Westfield, New Jersey. Metcalf is a graduate of the University of Michigan (BA 1968).
One of Metcalf's most notable roles is in the college comedy National Lampoon's Animal House (1978), in which he played the sadistic ROTC leader Doug Neidermeyer. He played a very similar character in the Twisted Sister music videos "We're Not Gonna Take It" (as the father) and "I Wanna Rock" (as a high school teacher). In each video he used his Animal House catchphrases: "A Twisted Sister pin?! On your uniform?!" and "You're all worthless and weak!", respectively.
He portrayed a very similar character in the movie The Stupids and the sitcom Teen Angel. He also starred in the 1986 comedy One Crazy Summer, as the sinister, greedy lobster loving Aquilla Beckerstead. In the police drama Hill Street Blues, Metcalf had an early key role in the first series as brash Officer Harris.
In Buffy the Vampire Slayer and its spin-off, Angel, Metcalf played the ancient vampire and original Big Bad, the Master. Coincidentally, he also played a character called "the Maestro" (real name: Bob Cobb) on two episodes of Seinfeld.
Metcalf works at First Stage Children's Theater. One of the plays he performed in was called The True Confessions of Charlotte Doyle, based on the novel by Avi. Another play he appeared in at First Stage was Holes in the early 2000s. He is a frequent guest on the Bob and Brian show on WHQG-FM and writes for Third Coast Digest. He is also a volunteer champion for the Alzheimer's Association to raise awareness about the disease, having written about the Alzheimer's documentary I Remember Better When I Paint.
- "Welcome to the Hellmouth"
- "The Harvest"
- "Never Kill a Boy on the First Date"
- "Prophecy Girl"
- "The Wish"
- Mark Metcalf on Wikipedia