A cyborg (cybernetic organism) was an organic creature of which synthetic enhancements/upgrades had been integrated into their bodies for the purpose of improving physical and/or mental capacities, although it was used for replacing lost limbs and recovering from serious injuries as well.
As part of their 314 Project, Initiative scientists Maggie Walsh and Francis Angleman designed special bio-mechanical demonoids, creatures combining the advancement of technology, the superior strength and emotional detachment of demons, and the intelligence and adaptability of humans into one being. Adam went rogue and killed his creators soon after being completed, and later performed a similar process on Forrest Gates after killing him. Both were slain by the Scooby Gang.
Shortly after taking over Wolfram & Hart's Los Angeles branch, Team Angel ran afoul of a mysterious organization of cyborg ninjas, who intended to use a mystical artifact to strip Angel of his free will and make him their slave.
The Pandora Project tested various animals, weaponizing them with robotics and the mystic energy drained from of supernatural folks (demons, vampires, witches, werewolves) in the Safe Zone. The magic was applied on battle suits and drones, but eventually animals and even humans, such as Rudy Diaz and Joanna Wise, combining biology, sorcery, and technology.