Despite not knowing who their Big Bad is, Buffy and the Scoobies know where the fruits of his or her evil labors are — and they're going in to destroy those fruits… er, maybe. Hopefully, along the way, they'll figure out who — or what — is behind the plot to remove magic from the world in time to save magical beings everywhere!
- The Pandora Project is compared to the Initiative, the organization from season 4.
- Faith reminds that, differently from Buffy, she and Spike have murdered people before: she killed the deputy mayor Allan Finch ("Bad Girls") and the vulcanologist Lester Worth ("Graduation Day, Part One"), while Spike was a human hunter himself.
- Previously at Sav-Mor Motel (The Great Escape), the Scoobies are hiding now at Windsor Arms Hotel.
- It's discovered that the Vice President of the United States is involved in the Pandora Project; he was shown with an energetic reaction to the San Francisco tsunami crisis, while President Malloy, not involved, had a more worried expression (The Spread of Their Evil).
- Xander mentions they've seem that absence of magic makes Dawn fade away, which is shown in Buffy Season Nine.
- Buffy considers having Dawn to open a portal to another dimension, an ability she gained through the Vampyr book in Own It, Part Five.
- Rudy Diaz
- Robert Dowling (Only mentioned)
- Xander Harris
- Faith Lehane
- Malloy (Only mentioned)
- Ophelia Reyes (Only mentioned)
- Willow Rosenberg
- Buffy Summers
- Dawn Summers
- Vice President of the United States
- Joanna Wise (Only mentioned)
- Vice President male bodyguard
- Vice President female bodyguard
- Financial Times reporter
Organization and Titles
- San Francisco
- Windsor Arms Motel
- Sunnydale (Only mentioned)
- Safe Zone (Only mentioned)
- Area 51 (Only mentioned)
- Canada (Only mentioned)
- Montana (Only mentioned)
Weapons and Objects
Rituals and Spells
- Spell of Forgetfulness
Behind the Scenes
- The variant cover features a "deleted scene" from the issue, written by Christos Gage and art by Megan Levens.
Pop Culture References
- Xander compares the idea of kidnapping the president to "the wonky seasons of The West Wing," the political drama TV series.
- The Vice President hastily confesses that the Area 51 is "heck of a story," a place largely focus of UFO conspiracy theories.
- Xander quotes Martin Luther King, the minister and activist who became the most visible spokesperson and leader in the Civil Rights Movement.
- As the Vice President, Xander accuses the reporter of "fake news," which mocks American President Donald Trump's habit of indiscriminately declare "fake news."
- The reporter is from Financial Times, an international daily newspaper with a special emphasis on business and economic news.
- Crimes Against Nature was among the 300 best selling comic issues in its publication month, with 10,050 sales in August 2017 at comic specialty stores.