He was the fight director for a stage production of Hamlet, and in 1991 he was the fight director of BBC's The Other Side, Romeo and Juliet, and The Soul's Dark Night. One of his first known works in television is on the arcade version of the video for "Got My Mind Set On You" by George Harrison. He had a small role in the movie First Knight.
Denisof appeared in three episodes of Sharpe as Lord John Rossendale. He has done many stage productions, including one with Anthony Stewart Head, who played Wesley's predecessor Rupert Giles on Buffy the Vampire Slayer.
Denisof's character was first introduced in Buffy season three, appearing in 9 episodes. He later showed up in episode 10 of the first season of Angel, and was an official main character from episode 11 (effectively replacing Doyle), appearing in 100 out of the 110 episodes of the series.
According to the DVD release of Angel's season 5, three weeks before the filming of the season premiere Denisof was stricken with Bell's palsy, from which he later recovered. Due to the paralysis of the left side of his face, scenes were structured as to not show its effects.
Denisof appears in season 2 of Private Practice as a man named Daniel, who has two pregnant wives giving birth on the same day. In 2006, Denisof began a recurring role as Sandy Rivers on Alyson Hannigan's series How I Met Your Mother. In 2012, Denisof reunited with Joss Whedon again in The Avengers as The Other, repeating his role in Guardians of the Galaxy. Since then, Denisof has portrayed the Prince Viktor on Grimm, David Wilson on Finding Carter, Glenn on I Love Bekka & Lucy, Adam Marsters on Chilling Adventures of Sabrina, and Rupert Vardemus on Legacies.
Denisof has appeared in both Buffy the Vampire Slayer and its spin-off Angel as the replacement then ex-Watcher Wesley Wyndam-Pryce. In the episode "Birthday," he additionally portrayed Wesley in the Cordy!verse alternative reality.
Buffy the Vampire Slayer
- "Bad Girls"
- "The Prom"
- "Graduation Day, Part One"
- "Graduation Day, Part Two"
- Angel season 1
- Angel season 2
- Angel season 3
- Angel season 4
- Angel season 5 (Credited but does no appear in "Destiny")
- "Buffy Wraps"
- "Season 3 Overview"
- "Angel Season 1 Overview"
- "I'm Cordelia!"
- "The Demons"
- "The Sets of Angel"
- "Action! The Stunts of Angel"
- "From Page to Screen"
- "Angel Season 3 Overview"
- "Malice in Wonderland: Wolfram & Hart"
- Audio commentary for "Spin the Bottle"
- "Angel Season 4 Overview"
- Audio commentary for "A Hole in the World"
- "It's Always Been About the Fans"
- "Angel 100"
- "The Final Season"
- Alexis Denisof on Wikipedia
- Stephen M. Silverman, "Buffy's Pals Alyson, Alexis Get Married." PEOPLE.com, October 14, 2003.