Spike and Dru (disambiguation)


 * Spike and Dru: Paint the Town Red, a comic book one-shot.
 * Spike and Dru: The Queen of Hearts, a comic book one-shot.
 * Spike and Dru: All's Fair, a comic book one-shot.
 * Spike and Dru: Who Made Who?, the comic book short story.
 * "Spike and Dru", the comic book collection.
 * "Spike and Dru: Pretty Maids All in a Row", the novel book.